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Commun Biol. 2019 Aug 19;2:315. doi: 10.1038/s42003-019-0560-x. eCollection 2019.

Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping.

Author information

1
1Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton, BN1 9QG UK.
2
2Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ UK.
3
3Bioinformatics Group, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG UK.
4
4Department of Neurosurgery, Hurstwood Park Neurosciences Centre, Brighton and Sussex University Hospitals, Brighton, UK.
5
5Department of Surgery and Cancer, Division of Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 ONN UK.
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Contributed equally

Abstract

Glioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options and biomarkers are limited. Small extracellular vesicles (sEVs) produced by both GBM and stromal cells are central in the inter-cellular communication that is taking place in the tumor bulk. As tumor sEVs are accessible in biofluids, recent reports have suggested that sEVs contain valuable biomarkers for GBM patient diagnosis and follow-up. The aim of the current study was to describe the protein content of sEVs produced by different GBM cell lines and patient-derived stem cells. Our results reveal that the content of the sEVs mirrors the phenotypic signature of the respective GBM cells, leading to the description of potential informative sEV-associated biomarkers for GBM subtyping, such as CD44. Overall, these data could assist future GBM in vitro studies and provide insights for the development of new diagnostic and therapeutic methods as well as personalized treatment strategies.

KEYWORDS:

Head and neck cancer; Tumour biomarkers

Conflict of interest statement

Competing interestsG.G. is an Editorial Board Member of Communications Biology, but was not involved in the editorial review of, nor the decision to publish, this article. The remaining authors declare no competing interests.

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