Advances in capillary electro-chromatography

Zhenkun Mao; Zilin Chen

doi:10.1016/j.jpha.2019.05.002

Advances in capillary electro-chromatography

J Pharm Anal. 2019 Aug;9(4):227-237. doi: 10.1016/j.jpha.2019.05.002. Epub 2019 May 11.

Authors

Zhenkun Mao^{1

2}, Zilin Chen^{1

2}

Affiliations

¹ Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
² State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing 10080, China.

Abstract

Capillary electrochromatography (CEC) is a micro-scale separation technique which is a hybrid between capillary electrophoresis (CE) and liquid chromatography (LC). CEC can be performed in packed, monolithic and open-tubular columns. In recent three years (from 2016 to 2018), enormous attention for CEC has been the development of novel stationary phases. This review mainly covers the development of novel stationary phases for open-tubular and monolithic columns. In particular, some biomaterials attracted increasing interest. There are no significant breakthroughs in technology and principles in CEC. The typical CEC applications, especially chiral separations are described.

Keywords: Capillary electrochromatography; Monolithic column; Novel stationary phases; Open-tubular column; Separation modes.

Publication types

Review