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Magn Reson Med. 2020 Jan;83(1):203-213. doi: 10.1002/mrm.27951. Epub 2019 Aug 27.

In vivo potassium MRI of the human heart.

Author information

1
Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
2
Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
3
Institute of Medical Physics, University of Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
4
Division of Medical Physics in Radiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
5
MRI.TOOLS GmbH, Berlin, Germany.

Abstract

PURPOSE:

Potassium ions (K+ ) play a critical role in cardiac electrophysiology, and changes in their concentration reflect pathophysiological processes related to cardiovascular diseases. Here, we investigated the feasibility of in vivo 39 K MRI of the human heart. To achieve this, we developed, evaluated, and applied a 39 K/1 H RF coil, which is tailored for 39 K MRI of human heart at 7.0T.

METHODS:

The performance of the 39 K/1 H RF coil was evaluated by electromagnetic field and specific absorption ratio simulations using 2 (male/female) human voxel models. The RF coil was evaluated at the bench and applied in an in vivo proof-of-principle study involving 7 healthy volunteers. The experiments were performed using a 7.0T whole-body MR system in conjunction with a 3D density-adapted projection reconstruction imaging technique.

RESULTS:

For in vivo 39 K MRI of the human heart, a nominal spatial resolution of 14.5 × 14.5 × 14.5 mm3 within a total scan time of 30 min was achieved. The average SNR within the heart was 9.6 ± 2.4.

CONCLUSION:

This work validates the design of a 39 K/1 H RF coil for cardiac MR at 7.0T and demonstrates for the first time in vivo the feasibility of 39 K MRI of the human heart.

KEYWORDS:

MRI; cardiac imaging; heart; potassium MRI; radio frequency coil; ultrahigh field MRI

PMID:
31452259
DOI:
10.1002/mrm.27951

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