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Vox Sang. 2019 Aug 27. doi: 10.1111/vox.12838. [Epub ahead of print]

Fresh frozen plasma and platelet concentrate storage duration not associated with in hospital mortality risk.

Ng MSY1,2,3, Hay K4, Choy J2,5, Middelburg RA6,7, Tung JP1,2,3, Fraser JF1,2.

Author information

1
Critical Care Research Group, The Prince Charles Hospital, Chermside, QLD, Australia.
2
Faculty of Medicine, Oral Health Centre, University of Queensland, Herston, QLD, Australia.
3
Research and Development, Australian Red Cross Blood Service, Kelvin Grove, QLD, Australia.
4
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
5
Royal Brisbane & Women's Hospital, Herston, QLD, Australia.
6
Centre for Clinical Transfusion Research, Sanquin Research, Leiden, Netherlands.
7
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

BACKGROUND AND OBJECTIVES:

To date, the effects of FFP and PC storage duration on mortality have only been studied in a few studies in limited patient subpopulations. The aim of the current study was to determine whether FFP and PC storage duration is associated with increased in hospital mortality risk across cardiac surgery, acute medicine, ICU and orthopaedic surgery patients.

MATERIALS AND METHODS:

Two-stage individual patient data meta-analyses were performed to determine the effects of FFP and PC storage duration on in hospital mortality. Preset random effects models were used to determine pooled unadjusted and adjusted (adjusted for age, gender and units of product transfused) effect estimates.

RESULTS:

The FFP storage duration analysis included 3625 patients across four studies. No significant association was observed between duration of storage and in hospital mortality in unadjusted analysis, but after adjusting for patient age, gender and units of product a small increased risk of in hospital mortality was observed for each additional month of storage (OR: 1·05, 95% CI: 1·01-1·08). This effect was no longer statistically significant when donor ABO blood group was incorporated into the random effects model on post hoc analyses. A total of 547 patients across five studies were incorporated in the PC storage duration analysis. No association was observed between PC storage duration and odds of in hospital morality (adjusted OR: 0·94, 95% CI: 0·79-1·11).

CONCLUSIONS:

There is insufficient evidence to support shortening FFP or PC shelf life based on in hospital mortality.

PMID:
31452207
DOI:
10.1111/vox.12838

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