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Cancer Causes Control. 2019 Nov;30(11):1223-1230. doi: 10.1007/s10552-019-01220-z. Epub 2019 Aug 26.

Green tea consumption and risk of hematologic neoplasms: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study).

Author information

1
Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.
2
Osaka Center for Cancer and Cardiovascular Disease Prevention, 1-6-107 Morinomiya, Osaka, 536-8588, Japan.
3
Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan.
4
Department of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan. yamagishi.kazumas.ge@u.tsukuba.ac.jp.
5
Department of Public Health, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.

Abstract

PURPOSE:

Experimental studies suggested that green tea may have an anticancer effect on hematologic neoplasms. However, few prospective studies have been conducted.

METHODS:

A total of 65,042 individuals aged 40-79 years participated in this study and completed a self-administered questionnaire about their lifestyle and medical history at baseline (1988-1990). Of these, 52,462 individuals living in 24 communities with information on incident hematologic neoplasms available in the cancer registry, who did not have a history of cancer and provided valid information on frequency of green tea consumption, were followed through 2009. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of hematologic neoplasms according to green tea consumption were analyzed.

RESULTS:

The incidence of hematologic neoplasms during a median follow-up of 13.3 years was 323. Compared with the never-drinkers of green tea, the multivariate HRs and 95% CIs for total hematologic neoplasms in green tea drinkers of ≤ 2 cups/day, 3-4 cups/day, and ≥ 5 cups/day were 0.65 (0.42-1.00), 0.73 (0.47-1.13), and 0.63 (0.42-0.96), respectively. The association was more prominent for acute myeloid leukemias and follicular lymphomas.

CONCLUSIONS:

The present cohort study suggests a protective effect of green tea against hematologic neoplasms, especially acute myeloid leukemias.

KEYWORDS:

Acute myeloid leukemia; Epigallocatechin-3-gallate; Green tea; Hematologic neoplasm; Japan collaborative cohort study for evaluation of cancer risk; Preventive medicine

PMID:
31452000
DOI:
10.1007/s10552-019-01220-z
[Indexed for MEDLINE]

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