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Diabetologia. 2019 Oct;62(10):1802-1810. doi: 10.1007/s00125-019-4919-9. Epub 2019 Aug 27.

Paternal impact on the life course development of obesity and type 2 diabetes in the offspring.

Author information

1
MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK. gemma.sharp@bristol.ac.uk.
2
Bristol Dental School, University of Bristol, Bristol, UK. gemma.sharp@bristol.ac.uk.
3
MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
4
Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
5
NIHR Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK.

Abstract

The aetiologies of obesity and type 2 diabetes are incredibly complex, but the potential role of paternal influences remains relatively understudied. A better understanding of paternal influences on offspring risk of obesity and type 2 diabetes could have profound implications for public health, clinical practice and society. In this review, we outline potential biological and social mechanisms through which fathers might exert an impact on the health of their offspring. We also present a systematically compiled overview of the current evidence linking paternal factors to offspring development of obesity and type 2 diabetes throughout the life course. Although evidence is accumulating to support paternal associations with offspring outcomes, more high-quality research is needed to overcome specific methodological challenges and provide stronger causal evidence.

KEYWORDS:

Developmental origins of health and disease; Epigenetics; Fathers; Life course development; Obesity; Paternal effects; Review; Type 2 diabetes

PMID:
31451867
PMCID:
PMC6731203
DOI:
10.1007/s00125-019-4919-9

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