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Trends Mol Med. 2019 Aug 22. pii: S1471-4914(19)30211-4. doi: 10.1016/j.molmed.2019.08.003. [Epub ahead of print]

The Sweet Kiss Breaching Immunological Self-Tolerance.

Author information

1
Istituto per l'Endocrinologia e l'Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (IEOS-CNR), 80131 Napoli, Italy.
2
Istituto per l'Endocrinologia e l'Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (IEOS-CNR), 80131 Napoli, Italy; Treg Cell Lab, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Napoli, Italy. Electronic address: giuseppe.matarese@unina.it.

Abstract

Metabolic alterations leading to overactivation of nutrient-energy-sensing pathways have been linked to altered immunological self-tolerance. Now, Zhang and colleagues (Immunity, 2019) have identified a key role for high glucose consumption in exacerbating autoimmunity in mice via induction of T helper (Th)17 cells. This reveals a novel mechanism underlying effects of diet during autoimmunity development with major translational implications.

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