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Asian Pac J Cancer Prev. 2019 Aug 1;20(8):2391-2396. doi: 10.31557/APJCP.2019.20.8.2391.

Retrospective Study of the Effect of Statins on the Outcome of Lung Cancer Patients, University of Cincinnati Experience.

Author information

1
Department of Hematology-Oncology, Division of Internal Medicine, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Ave, Cincinnati OH 45267, United States. Email: drs_olagaber@yahoo.com
2
Children Cancer Hospital, Cairo, Egypt.

Abstract

OBJECTIVES:

Numerous studies addressed the effect of statin on cancer patients. The aim of this study is to define the effect of statin administration with chemotherapy on the patients’ outcomes.

METHODS:

We retrospectively researched the database of the University of Cincinnati cancer to identify lung cancer patients who received statins (S+, n=41) during their treatment in our institute. We also, retrieved data for contemporaneously treated patients who did not receive statins (S-, n=159) as a control arm. Clinico-demographical data and overall survival (OS) were analyzed using Pearson’s Chi-square (χ2) test and Kaplan-Meier survival curves with Log-rank test. Adjustment using Cox proportional hazard ratios (HR) were done based on (age, gender, race and stage) to identify effect of statins on their outcomes.

RESULTS:

The median age for S+ was 64y (IQR; 55-69) and 71.2% of the patients were white. Histopathology was 55.4% and 31.7% for adenocarcinoma and squamous cell carcinoma, respectively. Fifty-six percent were stage IV in each study arm and the median OS was14.9 m. Median OS was insignificantly lower in S–ve arm (13.7 vs 15.6 months; P=0.652, HR=0.91, 95%CI 0.52-1.57). Our results show that after different types of adjustments, S+ did not show survival advantage (P>0.05) compared to the control arm.

CONCLUSION:

While showing an increase in overall survival in patients with advanced lung cancer, the results of this study did not reach statistical significance. This could be due for the small sample size of this retrospective study.

KEYWORDS:

Apoptosis; Lung cancer; Retrospective; Statins; survival

PMID:
31450911
DOI:
10.31557/APJCP.2019.20.8.2391
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