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Front Microbiol. 2019 Aug 6;10:1739. doi: 10.3389/fmicb.2019.01739. eCollection 2019.

Efomycins K and L From a Termite-Associated Streptomyces sp. M56 and Their Putative Biosynthetic Origin.

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Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, United States.
School of Pharmacy, Sungkyunkwan University, Suwon, South Korea.
Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Leibniz Institute for Natural Product Research and Infection Biology e.V., Hans-Knöll-Institute (HKI), Jena, Germany.


Two new elaiophylin derivatives, efomycins K (1) and L (2), and five known elaiophylin derivatives (3-7) were isolated from the termite-associated Streptomyces sp. M56. The structures were determined by 1D and 2D NMR and HR-ESIMS analyses and comparative CD spectroscopy. The putative gene cluster responsible for the production of the elaiophylin and efomycin derivatives was identified based on significant homology to related clusters. Phylogenetic analysis of gene cluster domains was used to provide a biosynthetic rational for these new derivatives and to demonstrate how a single biosynthetic pathway can produce diverse structures.


efomycin K; efomycin L; ela cluster; elaiophylin; gene cluster; termite-associated bacteria

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