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J Appl Microbiol. 2019 Aug 25. doi: 10.1111/jam.14424. [Epub ahead of print]

Developments in understanding and applying prebiotics in research and practice-an ISAPP conference paper.

Author information

1
Rowett Institute, University of Aberdeen, Aberdeen, UK.
2
Food and Nutritional Sciences, University of Reading, Reading, UK.
3
Metagenics (Aust) Pty Ltd., Virginia, Queensland, Australia.
4
Department of Crop Science, Universiti Putra Malaysia, Bintulu Campus, Malaysia.
5
Department of Allergy and Immunology, The Royal Children's Hospital, Parkville, Melbourne, VIC, Australia.
6
School of Biological Sciences, The University of Hong Kong, Hong Kong, Hong Kong.
7
Zespri International Ltd, Mt Maunganui, New Zealand.
8
Beneo-Institute, Obrigheim, Germany.
9
Departments of Obstetrics and Gynaecology and Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
10
The Bell Institute of Health and Nutrition, General Mills Inc., Minneapolis, MN, USA.
11
Nestlé Product and Technology Center Dairy, Konolfingen, Switzerland.
12
Reckitt Benckiser, Nijmegen, The Netherlands.
13
Ingredion Incorporated, Bridgewater, NJ, USA.

Abstract

AIMS:

The concept of using specific dietary components to selectively modulate the gut microbiota to confer a health benefit, defined as prebiotics, originated in 1995. In 2018, a group of scientists met at the International Scientific Association for Probiotics and Prebiotics annual meeting in Singapore to discuss advances in the prebiotic field, focussing on issues affecting functionality, research methodology and geographical differences.

METHODS AND RESULTS:

The discussion ranged from examining scientific literature supporting the efficacy of established prebiotics, to the prospects for establishing health benefits associated with novel compounds, isolated from different sources.

CONCLUSIONS:

While many promising candidate prebiotics from across the globe have been highlighted in preliminary research, there are a limited number with both demonstrated mechanism of action and defined health benefits as required to meet the prebiotic definition. Prebiotics are part of a food industry with increasing market sales, yet there are great disparities in regulations in different countries. Identification and commercialization of new prebiotics with unique health benefits means that regulation must improve and remain up-to-date so as not to risk stifling research with potential health benefits for humans and other animals.

SIGNIFICANCE AND IMPACT OF STUDY:

This summary of the workshop discussions indicates potential avenues for expanding the range of prebiotic substrates, delivery methods to enhance health benefits for the end consumer and guidance to better elucidate their activities in human studies.

KEYWORDS:

ISAPP; gut fermentation; health benefits; microbiome; prebiotics

PMID:
31446668
DOI:
10.1111/jam.14424

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