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Qual Life Res. 2019 Aug 24. doi: 10.1007/s11136-019-02271-0. [Epub ahead of print]

Depressive symptoms, physical symptoms, and health-related quality of life among older adults with HIV.

Author information

1
School of Public Health, Yale University, New Haven, CT, USA.
2
School and Department of Medicine, Center for AIDS Prevention Studies, University of California, San Francisco, San Francisco, CA, USA.
3
Department of Medicine, AIDS Program, Yale University School of Medicine, New Haven, CT, USA.
4
Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.
5
College of Public Health, University of Georgia, Athens, GA, USA.
6
College of Public Health, University of Georgia, Athens, GA, USA. nhansen@uga.edu.
7
Department of Health Promotion and Behavior, College of Public Health, University of Georgia, 131 Wright Hall, Health Sciences Campus, Athens, GA, 30602, USA. nhansen@uga.edu.

Abstract

PURPOSE:

In the United States, approximately 45% of persons living with HIV (PLHIV) are ≥ 50 years of age. Many older PLHIV have multi-morbidities that complicate HIV infection and/or interfere with, or are exacerbated by, antiretroviral treatment. Physical health symptoms and psychiatric disorders, particularly depression, can worsen life quality in older PLHIV.

METHODS:

This study assessed associations among physical symptoms, indicators of HIV-related health status (i.e., time since diagnosis; ever diagnosed with AIDS; having attained viral suppression), depressive symptoms, and health-related quality of life (HRQoL) in older PLHIV. Regression analyses examined data from 296 PLHIV ≥ 50 years of age living in Cincinnati, OH, Columbus, OH, and New York City.

RESULTS:

Depressive symptoms and physical symptoms, particularly those related to appearance and sexual functioning, most strongly predicted HRQoL. Indicators of HIV health status did not significantly predict HRQoL. Depressive symptoms were a particularly robust predictor of HRQoL, even when accounting for physical health symptoms.

CONCLUSION:

Findings suggest that symptom management is critical to HRQoL in older PLHIV, and symptoms related to physical appearance and sexual functioning should not be overlooked in this growing population.

KEYWORDS:

Aging; Depression; HIV/AIDS; Physical symptoms; Quality of life

PMID:
31446515
DOI:
10.1007/s11136-019-02271-0

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