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Ann Allergy Asthma Immunol. 2019 Nov;123(5):444-453. doi: 10.1016/j.anai.2019.08.012. Epub 2019 Aug 23.

Antibody deficiency testing for primary immunodeficiency: A practical review for the clinician.

Author information

1
Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio; Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
2
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York; NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, New York.

Abstract

OBJECTIVE:

To review selected published studies related to the diagnostic evaluation of antibody deficiency.

DATA SOURCES:

Published literature.

STUDY SELECTIONS:

Studies related to the diagnostic evaluation of antibody deficiency and existing recommendations were selected.

RESULTS:

Many primary immunodeficiency diseases include humoral deficiency. Practical tests used in the clinical evaluation of patients for possible antibody deficiency include immunoglobulin measurement, specific antibody titers, and B-cell enumeration and phenotyping.

CONCLUSION:

Clinically available tests can be used to readily evaluate patients for antibody deficiencies.

PMID:
31446132
DOI:
10.1016/j.anai.2019.08.012

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