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Vaccine. 2019 Sep 16;37(39):5807-5811. doi: 10.1016/j.vaccine.2019.08.024. Epub 2019 Aug 22.

Comparison of vaccine effectiveness against influenza hospitalization of cell-based and egg-based influenza vaccines, 2017-2018.

Author information

1
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States. Electronic address: katia.bruxvoort@kp.org.
2
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States. Electronic address: Yi.X.Luo@kp.org.
3
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States. Electronic address: Bradley.K.Ackerson@kp.org.
4
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States. Electronic address: Hilary.Tanenbaum@kp.org.
5
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States. Electronic address: Lina.S.Sy@kp.org.
6
Seqirus, Summit, NJ, United States. Electronic address: Ashesh.Gandhi@Seqirus.com.
7
Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States. Electronic address: Hung-Fu.X.Tseng@kp.org.

Abstract

Egg-based influenza vaccines could be less effective than cell-based vaccine due to adaptive mutations acquired for growth. We conducted a test-negative case-control study at Kaiser Permanente Southern California to assess vaccine effectiveness (VE) against hospitalization for laboratory-confirmed influenza during 2017-2018. Among the 1186 cases and 6946 controls, 74% and 59%, respectively, were ages ≥ 65 years. For any influenza, the adjusted relative VE of cell-based vaccine versus egg-based vaccines was 43% (95% CI: -45% to 77%) for patients ages < 65 years and 6% (95% CI: -46% to 39%) for patients ages ≥ 65 years. For influenza A(H3N2), the adjusted relative VE was 61% (95% CI: -63% to 91%) for patients ages < 65 years and -4% (95% CI: -70% to 37%) for patients ages ≥ 65 years. Statistically significant protection against influenza hospitalization of cell-based vaccine compared to egg-based vaccines was not observed, but further studies in additional influenza seasons are warranted.

KEYWORDS:

Influenza; Influenza vaccine; Vaccine effectiveness

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