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Neuropsychopharmacology. 2019 Aug 23. doi: 10.1038/s41386-019-0486-5. [Epub ahead of print]

Sleep disturbance in PTSD and other anxiety-related disorders: an updated review of clinical features, physiological characteristics, and psychological and neurobiological mechanisms.

Author information

1
The San Francisco VA Health Care System, San Francisco, CA, USA. Anne.richards@ucsf.edu.
2
The University of California, San Francisco, San Francisco, CA, USA. Anne.richards@ucsf.edu.
3
The San Francisco VA Health Care System, San Francisco, CA, USA.
4
The University of California, San Francisco, San Francisco, CA, USA.

Abstract

The current report provides an updated review of sleep disturbance in posttraumatic stress disorder and anxiety-related disorders. First, this review provides a summary description of the unique and overlapping clinical characteristics and physiological features of sleep disturbance in specific DSM anxiety-related disorders. Second, this review presents evidence of a bidirectional relationship between sleep disturbance and anxiety-related disorders, and provides a model to explain this relationship by integrating research on psychological and neurocognitive processes with a current understanding of neurobiological pathways. A heuristic neurobiological framework for understanding the bidirectional relationship between abnormalities in sleep and anxiety-related brain pathways is presented. Directions for future research are suggested.

PMID:
31443103
DOI:
10.1038/s41386-019-0486-5

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