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Cell. 2019 Aug 22;178(5):1038-1040. doi: 10.1016/j.cell.2019.07.052.

When Fasting Gets Tough, the Tough Immune Cells Get Going-or Die.

Author information

1
Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA.
2
Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089-0191, USA; IFOM FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milan, Italy; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: vlongo@usc.edu.

Abstract

Cycles of fasting reduce autoimmunity and activate lymphocyte-dependent killing of cancer cells, but the mechanisms remain poorly understood. Three studies in this issue of Cell begin to reveal the drastic and complex effects of fasting and severe calorie restriction on the levels and localization of different immune cells and the mechanisms responsible for them.

PMID:
31442398
DOI:
10.1016/j.cell.2019.07.052

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