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Proteins. 2019 Aug 23. doi: 10.1002/prot.25805. [Epub ahead of print]

Target highlights in CASP13: Experimental target structures through the eyes of their authors.

Author information

1
BSC-CNS Barcelona Supercomputing Center, Barcelona, Spain.
2
Genome Center, University of California, Davis, California.
3
Biosciences Center, National Renewable Energy Laboratory, Golden, Colorado.
4
Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany.
5
Nuffield Department of Medicine; Structural Genomics Consortium, University of Oxford, Oxford, UK.
6
School of Biochemistry, University of Bristol, Bristol, UK.
7
Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada.
8
Department of BioSciences, Rice University, Houston, Texas.
9
Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, Wisconsin.
10
Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
11
School of Biological Sciences, University of Auckland, Auckland, New Zealand.
12
Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, Grenoble, France.
13
Institute of Food, Nutrition and Health, Zurich, Switzerland.
14
Department of Molecular Biology and Biochemistry; Pharmaceutical Sciences, University of California Irvine, Irvine, California.
15
School of Biosciences, University of Birmingham, Birmingham, UK.
16
Department of Molecular, Cellular and Developmental Biology, Biomolecular Science and Engineering Program, University of California, Santa Barbara, California.
17
Structural Biology Center, Biosciences Division, Midwest Center for Structural Genomics, Argonne.
18
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois.
19
Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas.
20
Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.
21
Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois.
22
Institute for Bioscience and Biotechnology Research, Department of Cell Biology and Molecular genetics, University of Maryland, Rockville, Maryland, USA.
23
Institute of Structural and Molecular Biology, Birkbeck, University College London, London, UK.
24
Great Lakes Bioenergy Research Center and Department of Plant Biology, Michigan State University, East Lansing, Michigan.
25
Biozentrum University of Basel, Basel, Switzerland.
26
SIB Swiss Institute of Bioinformatics, Biozentrum University of Basel, Basel, Switzerland.

Abstract

The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP13 experiment.

KEYWORDS:

CASP, protein structure prediction; X-ray crystallography; cryo-EM

PMID:
31442339
DOI:
10.1002/prot.25805

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