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J Cosmet Dermatol. 2019 Aug 23. doi: 10.1111/jocd.13099. [Epub ahead of print]

Evaluation of moisturizing and irritation potential of sacha inchi oil.

Author information

1
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.
2
Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand.
3
Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
4
Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.
5
Cosmetics and Natural Products Research Center, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.

Abstract

OBJECTIVE:

The moisturizing and irritation effects of sacha inchi oil were evaluated.

STUDY DESIGN:

The moisturizing effect on the skin was clinically assessed using a regression study design. Sacha inchi oil or olive oil (benchmark) was applied on the left or right lower leg of the subjects for 14 days followed by application discontinuation for 2 days. The TEWL, skin moisture content and dryness appearance were observed.

METHODS:

The fatty acid composition and characteristics of cold-pressed sacha inchi seed oil were determined. Skin tissues cultured ex vivo were used to assess primary irritation induced by the oil by examining keratin 1 expression and TNF-α and IL-1α release from the oil-applied tissues.

RESULTS:

The sacha inchi oil contained 42.3% linolenic acid and 39.5% linoleic acid. This oil's saponification, iodine, acid and peroxide values were 168.58 ± 1.55 mg KOH/g, 203.00 ± 0.04 g I2 /100 g, 1.68 ± 0.03 mg KOH/g, and 1.95 ± 0.26 mEq peroxide/kg, respectively. Compared with nontreated skin tissues, induced secretion of TNF-α and IL-1α and disruption of keratin 1 integrity in the stratum corneum layer were not found in the sacha inchi oil-treated tissues. In a clinical study with 13 volunteers, the improvement in moisture content and skin dryness appearance at the sacha inchi oil-applied site was comparable with that observed at the olive oil-applied site.

CONCLUSIONS:

The sacha inchi oil was mild to the skin and benefited dry skin.

KEYWORDS:

irritation; moisturizing effect; olive oil; sacha inchi oil

PMID:
31441999
DOI:
10.1111/jocd.13099

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