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Medicine (Baltimore). 2019 Aug;98(34):e16964. doi: 10.1097/MD.0000000000016964.

The clinical effects of antibiotic prophylaxis for hysteroscopic procedures: A meta-analysis.

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Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan.
Department of Reproductive Medicine Center, Hubei Maternal and Child Health Hospital.
School of Nursing, Huanggang Polytechnic College, Huanggang, PR China.



Hysteroscopic procedures were widely applied but the clinical effects of antibiotic prophylaxis for these operations were not specifically addressed. In current study, we aimed to investigate the role of prophylactic antibiotics in hysteroscopic procedures by meta-analysis.


We conducted literature retrieval in electronic databases, including MEDLINE, EMBASE, and Cochrane Central, to identify relevant randomized controlled trials (RCTs) investigating the clinical effects of antibiotic prophylaxis for hysteroscopic procedures. The postoperative infection rate was selected for pooled estimation. The I index statistic was used to assess heterogeneity. Publication bias was evaluated using funnel plots and Egger test. Sensitivity analysis based on different subcategories was conducted to examine the stability of the main results.


Four RCTs including 2221 patients were identified for the final quantitative analysis. Pooled estimation indicated no significant difference in infection rate between the antibiotic prophylaxis group and control group (test for OR: Zā€Š=ā€Š0.50, Pā€Š=ā€Š.616; 95% CI: 0.987-1.008). Sensitivity analysis based on surgical procedure, antibiotic application, follow-up time and administration time revealed similar results.


Based on current objective evidence, we conclude that antibiotic prophylaxis exhibits no clinical benefit for hysteroscopic procedures. Therefore, it is not recommended. Meanwhile, more high-quality RCTs are needed to support our conclusion.

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