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Medicine (Baltimore). 2019 Aug;98(34):e16865. doi: 10.1097/MD.0000000000016865.

Ozone and pulsed electro-magnetic field therapies improve endometrial lining thickness in frozen embryo transfer cycles: Three case reports.

Author information

1
Department of Biochemistry, Albert Einstein College of Medicine Bronx.
2
New Hope Fertility Center, New York, NY.
3
HOCATT USA LLC, Weatherford, TX.

Abstract

RATIONALE:

In assisted reproductive technology, a persistently thin endometrial lining represents a huge challenge during frozen embryo transfer (FET) cycles.

PATIENT CONCERNS:

Three patients who had a persistently thin endometrial lining despite the use of several medical agents known to improve endometrial lining thickness.

DIAGNOSES:

Infertility undergoing FET cycles.

INTERVENTIONS:

A combination of transdermal and intravaginal ozone therapy along with Pulsed Electro-Magnetic Field (PEMF) therapy.

OUTCOMES:

Ozone with PEMF, both of which are known to have vasodilatatory, anti-inflammatory, and anti-oxidant actions, were successful in improving the thickness of the endometrial lining in all 3 patients. Two out of 3 patients became pregnant following single embryo transfer.

LESSONS:

Ozone with PEMF constitute a novel experimental approach for women with persistently thin endometrial lining undergoing FET. This novel approach needs validation by large well-designed studies.

PMID:
31441861
DOI:
10.1097/MD.0000000000016865
[Indexed for MEDLINE]
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