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Protein Sci. 2019 Aug 22. doi: 10.1002/pro.3715. [Epub ahead of print]

Toward understanding the origin and evolution of cellular organisms.

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Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan.


In this era of high-throughput biology, bioinformatics has become a major discipline for making sense out of large-scale datasets. Bioinformatics is usually considered as a practical field developing databases and software tools for supporting other fields, rather than a fundamental scientific discipline for uncovering principles of biology. The KEGG resource that we have been developing is a reference knowledge base for biological interpretation of genome sequences and other high-throughput data. It is now one of the most utilized biological databases because of its practical values. For me personally, KEGG is a step toward understanding the origin and evolution of cellular organisms.


KEGG; KEGG MEDICUS; KEGG module; pathway mapping; reaction module


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