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Innov Clin Neurosci. 2019 May 1;16(5-6):30-37.

ADULT NEUROGENESIS IN HUMANS: A Review of Basic Concepts, History, Current Research, and Clinical Implications.

Kumar A1,2,3,4,5,6, Pareek V1,2,3,4,5,6, Faiq MA1,2,3,4,5,6, Ghosh SK1,2,3,4,5,6, Kumari C1,2,3,4,5,6.

Author information

1
Drs. Kumar and Ghosh are with the Department of Anatomy at the All India Institute of Medical Sciences (AIIMS) in Patna, India.
2
Dr. Pareek is with the Computational Neuroscience and Neuroimaging Division at National Brain Research Centre (NBRC) in Manesar, Haryana, India.
3
Dr. Faiq is with the Neuroimaging and Visual Science Laboratory at Langone Medical Centre, New York University School of Medicine in New York, New York.
4
Dr. Kumari is with the Department of Anatomy at Postgraduate Institute of Medical Education and Research (PGIMER) in Chandigarh, India.
5
Drs. Kumar and Faiq are with All India Institute of Medical Sciences (AIIMS) in New Delhi, India.
6
Drs. Kumar, Pareek, Faiq, Ghosh, and Kumari are with the Etiologically Elusive Disorders Research Network (EEDRN) in New Delhi, India.

Abstract

Neurogenesis in adult humans remains a controversial area of research among neuroscientists. Methodological challenges have hampered investigators from conducting high-quality, in-vivo studies that can help elucidate the presence and/or activity of neurogenesis in human brains. Additionally, the studies that have been done in humans report conflicting results, further adding to the ambiguity surrounding the concept of adult neurogenesis in humans. In this review article, the authors seek to help clarify the concept of adult neurogenesis by providing an overview of the basic concept, as we currently understand it, including its historical birth and evolution. The authors also review and discuss current key studies (pro and con) on adult neurogenesis in humans and animals, as well as research challenges with potential solutions. Finally, the authors discuss the clinical implications of adult neurogenesis in humans, based on what we know so far, including its potential use as a drug target in the development of pharmacological treatments for various neuropsychiatric disorders.

KEYWORDS:

Adult human neurogenesis; aging; hippocampus; neuropsychiatric disorders; neurorestoration; olfactory bulb

PMID:
31440399
PMCID:
PMC6659986

Conflict of interest statement

FUNDING: No funding was provided. DISCLOSURES: The authors have no conflicts of interest relevant to the content of this article.

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