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Nat Struct Mol Biol. 2019 Sep;26(9):771-776. doi: 10.1038/s41594-019-0283-1. Epub 2019 Aug 22.

The hunt for RNA polymerase II elongation factors: a historical perspective.

Author information

1
Stowers Institute for Medical Research, Kansas City, MO, USA.
2
Department of Biochemistry & Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA.
3
Stowers Institute for Medical Research, Kansas City, MO, USA. jlc@stowers.org.
4
Department of Biochemistry & Molecular Biology, University of Kansas Medical Center, Kansas City, KS, USA. jlc@stowers.org.

Abstract

The discovery of the three eukaryotic nuclear RNA polymerases paved the way for serious biochemical investigations of eukaryotic transcription and the identification of eukaryotic transcription factors. Here we describe this adventure from our vantage point, with a focus on the hunt for factors that regulate elongation by RNA polymerase II.

PMID:
31439940
DOI:
10.1038/s41594-019-0283-1

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