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Diagnostics (Basel). 2019 Aug 21;9(3). pii: E100. doi: 10.3390/diagnostics9030100.

Design and Benchmark Testing for Open Architecture Reconfigurable Mobile Spirometer and Exhaled Breath Monitor with GPS and Data Telemetry.

Author information

1
Department of Mechanical and Aerospace Engineering, University of California, Davis, CA 95616, USA.
2
Department of Internal Medicine, 4150 V Street, Suite 3400, University of California, Davis, Sacramento, CA 95817, USA.
3
VA Northern California Health Care System, 10535 Hospital Way, Mather, CA 95655, USA.
4
Department of Mechanical and Aerospace Engineering, University of California, Davis, CA 95616, USA. cedavis@ucdavis.edu.
5
Department of Internal Medicine, 4150 V Street, Suite 3400, University of California, Davis, Sacramento, CA 95817, USA. njkenyon@ucdavis.edu.
6
VA Northern California Health Care System, 10535 Hospital Way, Mather, CA 95655, USA. njkenyon@ucdavis.edu.
7
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USA. njkenyon@ucdavis.edu.

Abstract

Portable and wearable medical instruments are poised to play an increasingly important role in health monitoring. Mobile spirometers are available commercially, and are used to monitor patients with advanced lung disease. However, these commercial monitors have a fixed product architecture determined by the manufacturer, and researchers cannot easily experiment with new configurations or add additional novel sensors over time. Spirometry combined with exhaled breath metabolite monitoring has the potential to transform healthcare and improve clinical management strategies. This research provides an updated design and benchmark testing for a flexible, portable, open access architecture to measure lung function, using common Arduino/Android microcontroller technologies. To demonstrate the feasibility and the proof-of-concept of this easily-adaptable platform technology, we had 43 subjects (healthy, and those with lung diseases) perform three spirometry maneuvers using our reconfigurable device and an office-based commercial spirometer. We found that our system compared favorably with the traditional spirometer, with high accuracy and agreement for forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), and gas measurements were feasible. This provides an adaptable/reconfigurable open access "personalized medicine" platform for researchers and patients, and new chemical sensors and other modular instrumentation can extend the flexibility of the device in the future.

KEYWORDS:

breath analysis; personalized medicine; spirometry; telehealth

PMID:
31438639
DOI:
10.3390/diagnostics9030100
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