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Bioinformation. 2019 Feb 28;15(2):116-120. doi: 10.6026/97320630015116. eCollection 2019.

Re-positioning of known drugs for Pim-1 kinase target using molecular docking analysis.

Author information

1
Biotechnology Laboratory (Medbiotech),BioInova Research center,Rabat Medical and Pharmacy School,Mohammed V University in Rabat,Rabat,Morroco.

Abstract

The Concept of reusing existing drugs for new targets is gaining momentum in recent years because of cost-effectiveness as safety and toxicology data are already available. Therefore, it is of interest to re-profile known drugs against the Pim-1 kinase target using molecular docking analysis. Results show that known drugs such as nilotinib, vemurafenib, Idelalisib, and other small kinases inhibitors have high binding ability with Pim-1 kinase for consideration as potential inhibitors.

KEYWORDS:

Pim-1 kinase; drug re-profiling; small kinases inhibitors

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