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Curr Drug Targets. 2019 Aug 21. doi: 10.2174/1389450120666190821153557. [Epub ahead of print]

Circulating exosomes and their role in stroke.

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Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.
Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad. Iran.
Academic Center for Education, Culture and Research (ACECR)-Khorasan Razavi, Mashhad. Iran.
Department of Neurology, Mashhad University of Medical Sciences, Mashhad. Iran.


Stroke is an acute neurologic disorder which can be life threatening if left untreated or diagnosed lately. Various detecting techniques including neurologic imaging of brain by computed tomography or magnetic resonance imaging can facilitate diagnosis of stroke. However, according to the recent advances in molecular detection techniques new diagnostic and prognostic has been emerged. Exosomes as an extra cellar particle are one of these markers which can have useful diagnostic, prognostic and even therapeutic impact after stroke. We have previously discussed the role of exosomes in cardiovascular disease and in the present review we focus on the most common cerebrovascular disease. The aim of present review is summarizing the recent diagnostic role of exosomes which are specifically secreted during stroke and can guide clinicians to better diagnosis of stroke.


cerebrovascular disease; diagnosis; exosome; microRNA; stroke; thrombosis

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