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Eur Radiol Exp. 2019 Aug 21;3(1):32. doi: 10.1186/s41747-019-0113-6.

In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica.

Author information

1
KlusLab Research, Witikonerstrasse 15, CH 8032, Zürich, Switzerland.
2
Institute for Diagnostic and Interventional Radiology, University Hospital Zürich, University of Zürich, 8006, Zurich, Switzerland.
3
KlusLab Research, Witikonerstrasse 15, CH 8032, Zürich, Switzerland. john.froehlich@kluslab.ch.

Abstract

Computed tomography can provide high-resolution details on nasal anatomy being potentially useful for the assessment of nasal spray deposition. The purpose of this technical note was to present a method based on CT imaging to assess qualitatively and quantitatively the in vitro spray deposition patterns within the sinonasal cavities of a nasal replica obtained by three-dimensional (3D) printing, using iodinated contrast agent labelled solutions with high spatial and temporal resolution. Using a third generation dual-source CT scanner in single energy mode, scans of a nasal replica were acquired following application of iodinated contrast agent labelled aerosols with an iodine concentration of 92.5 mgl/mL. Two software programmes were then utilised (Osirix MD v.9.0, Pixmeo, Geneva, Switzerland; 3mensio, Pie Medical Imaging, Bilthoven, Netherlands) to generate three-dimensional reconstructions of the scans, thus enabling the rapid detection and visualisation of administered single droplets and their voxel-by-voxel localisation. Using this approach, we achieved recovery rates between 84-98% and 89-109% (depending on the software programme) of the total applied aerosol volume.

KEYWORDS:

Aerosols; Contrast media; Iodine; Nasal sprays; Tomography (x-ray computed)

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