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Nature. 1988 Nov 17;336(6196):222-5.

Unresponsiveness to a foreign antigen can be caused by self-tolerance.

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1
Basel Institute for Immunology, Switzerland.

Abstract

In mice, two sets of genes govern the immune response to the synthetic antigen GT. One maps to the major histocompatibility complex and behaves like a typical immune response gene. The second is a background gene encoding a cell surface structure found on B cells. Mice which express, and are therefore tolerant of, one form of this structure do not respond to GT. Thus, tolerance of self generates holes in the T-cell repertoire, partially crippling the immune system.

PMID:
3143074
DOI:
10.1038/336222a0
[Indexed for MEDLINE]
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