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Dev Cell. 2019 Aug 19;50(4):393-394. doi: 10.1016/j.devcel.2019.07.028.

Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics.

Author information

1
The Graduate Program of Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
2
Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto 606-8501, Japan. Electronic address: kageyama.ryoichiro.8r@kyoto-u.ac.jp.

Abstract

In this issue of Developmental Cell,Lee et al. (2019) and Falo-Sanjuan et al. (2019) examine the transcriptional dynamics of Notch signaling in vivo. Both groups show that Notch signaling produces "bursty" transcriptional responses and that variance in these responses stems from changes in duration, not frequency, of transcriptional bursts.

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