Format

Send to

Choose Destination
J Pediatr. 1988 Dec;113(6):1074-7.

Abnormalities of diaphragmatic muscle in neonates with ventilated lungs.

Author information

1
Program in Developmental Pathology, Brown University, Providence, RI.

Abstract

Several infants and neonates who had received long-term ventilatory assistance had subnormal diaphragmatic muscle mass on gross necropsy examination. We conducted a retrospective study of our hospital infant necropsy files to determine whether prolonged ventilatory support was associated with diminution in myofiber cross-sectional area selectively affecting the diaphragm. We found that long-term ventilatory assistance may predispose diaphragmatic myofibers to disuse atrophy or to failure or normal growth. This phenomenon may contribute to difficulties in weaning infants from ventilatory support.

PMID:
3142983
DOI:
10.1016/s0022-3476(88)80585-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center