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Food Funct. 2019 Sep 1;10(9):5555-5565. doi: 10.1039/c9fo01152h. Epub 2019 Aug 20.

Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1α/Nrf2 pathway.

Author information

1
College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. zhangzhigang@neau.edu.cn 1270293250@qq.com.
2
College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China. zhangzhigang@neau.edu.cn 1270293250@qq.com and Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Harbin, 150030, China.

Abstract

Exposure to chromium (Cr) causes a number of respiratory diseases, including lung cancer and pulmonary fibrosis. However, there is currently no safe treatment for Cr-induced lung damage. Here, we used in vivo and in vitro approaches to examine the protective effects of melatonin (MEL) on Cr-induced lung injury and to identify the underlying molecular mechanisms. We found that treatment of rats or a mouse lung epithelial cell MLE-12 with MEL attenuated K2Cr2O7-induced lung injury by reducing the production of oxidative stress and inflammatory mediators and inhibiting cell apoptosis. MEL treatment upregulated the expression of silent information regulator 1 (Sirt1), which deacetylated the transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-1α (Pgc-1α). In turn, this increased the expression of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) and key anti-oxidant target genes. These results suggest that melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1α/Nrf2 pathway. Dietary MEL supplement may be a potential new strategy for the treatment of Cr poisoning.

PMID:
31429458
DOI:
10.1039/c9fo01152h

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