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Clin Case Rep. 2019 Jul 16;7(8):1608-1611. doi: 10.1002/ccr3.2299. eCollection 2019 Aug.

Homozygous familial hypercholesterolemia with stenosis of the left anterior descending coronary artery successfully treated with weekly low-density lipoprotein apheresis for 16 years without percutaneous coronary intervention.

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Department of Cardiovascular Medicine and Nephrology Dokkyo Medical University Nikko Medical Center Nikko Japan.
Yuai Clinic Saitama Japan.
Department of First Integrated Medicine 1, Saitama Medical Center Jichi Medical University Saitama Japan.
Department of Cardiovascular Surgery Sakakibara Heart Institute Tokyo Japan.
Department of Cardiovascular Medicine Dokkyo Medical University Mibu Japan.


We successfully treated a patient with homozygous familial hypercholesterolemia (HoFH) with stable coronary arterial disease using optimal medical therapy and low-density lipoprotein (LDL) apheresis for 16 years without percutaneous coronary intervention or bypass surgery. Intensive LDL lowering using apheresis and medication protected the patient from coronary atherosclerotic progression even in HoFH.


angina; apheresis; homozygous familial hypercholesterolemia; iodine allergy

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