Format

Send to

Choose Destination
Cancer Epidemiol Biomarkers Prev. 2019 Aug 19. doi: 10.1158/1055-9965.EPI-19-0577. [Epub ahead of print]

Prediagnostic Leukocyte Telomere Length and Pancreatic Cancer Survival.

Author information

1
Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts. hamada-tky@umin.ac.jp.
2
Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
3
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
4
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
5
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
6
Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
7
University of Washington School of Nursing, Seattle, Washington.
8
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
9
Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Jamaica Plain, Massachusetts.
10
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
11
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
12
Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
13
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.
14
Yale Cancer Center, New Haven, Connecticut.
15
Department of Medicine, Yale School of Medicine, New Haven, Connecticut.
16
Smilow Cancer Hospital, New Haven, Connecticut.
17
Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
18
Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts.
#
Contributed equally

Abstract

BACKGROUND:

Leukocyte telomere length has been associated with risk of subsequent pancreatic cancer. Few prospective studies have evaluated the association of prediagnostic leukocyte telomere length with pancreatic cancer survival.

METHODS:

We prospectively examined the association of prediagnostic leukocyte telomere length with overall survival (OS) time among 423 participants diagnosed with pancreatic adenocarcinoma between 1984 and 2008 within the Health Professionals Follow-up Study, Nurses' Health Study, Physicians' Health Study, and Women's Health Initiative. We measured prediagnostic leukocyte telomere length in banked blood samples using quantitative PCR. Cox proportional hazards models were used to estimate HRs for OS with adjustment for potential confounders. We also evaluated 10 SNPs at the telomerase reverse transcriptase locus.

RESULTS:

Shorter prediagnostic leukocyte telomere length was associated with reduced OS among patients with pancreatic cancer (P trend = 0.04). The multivariable-adjusted HR for OS comparing the lowest with highest quintiles of leukocyte telomere length was 1.39 (95% confidence interval, 1.01-1.93), corresponding to a 3-month difference in median OS time. In an analysis excluding cases with blood collected within 2 years of cancer diagnosis, the association was moderately stronger (HR, 1.55; 95% confidence interval, 1.09-2.21; comparing the lowest with highest quintiles; P trend = 0.01). No prognostic association or effect modification for the prognostic association of prediagnostic leukocyte telomere length was noted in relation to the studied SNPs.

CONCLUSIONS:

Prediagnostic leukocyte telomere length was associated with pancreatic cancer survival.

IMPACT:

Prediagnostic leukocyte telomere length can be a prognostic biomarker in pancreatic cancer.

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center