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Diabetes Metab Syndr. 2019 Jul 30;13(5):2819-2825. doi: 10.1016/j.dsx.2019.07.045. [Epub ahead of print]

The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials.

Author information

1
Faculty Research Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, UK. Electronic address: cain_1234@hotmail.co.uk.
2
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: ehsanghaedi073@gmail.com.
3
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research center, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: arman4369@gmail.com.
4
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: makan.pourmasoumi@gmail.com.
5
Halal Research Center of IRI, FDA, Tehran, Iran. Electronic address: amirhadi.vnt@gmail.com.

Abstract

OBJECTIVE:

Our objective was to perform a systematic review and meta-analysis on randomized controlled trials (RCTs) assessing the effect of curcumin on serum adiponectin concentration.

METHODS:

We searched PubMed/Medline, Scopus, ISI Web of Science, Cochrane Library, and Google scholar databases up to April 2019. RCTs conducted among human adults studied the effects of curcumin on serum adiponectin concentrations as an outcome variable was included. The weighted mean differences (WMD) and standard deviations (SD) of change in serum adiponectin levels were calculated. The random effects model was used for deriving a summary of mean estimates with their corresponding SDs.

RESULTS:

Out of 313 records, 6 trials that enrolled 652 subjects were included. The pooled results showed that curcumin supplementation significantly increased adiponectin concentrations in comparison with placebo (WMD: 0.82 Hedges' g; 95% confidence interval (CI): 0.33 to 1.30, P˂0.001). Greater effects on adiponectin were observed in trials lasting ≤10 weeks (WMD: 1.05 Hedges' g; 95% CI: 0.64 to 1.45, P˂0.001).

CONCLUSION:

Curcumin significantly improves adiponectin concentrations. However, due to some limitations in this study, further studies are needed to reach a definitive conclusion about the effect of curcumin on the levels of adiponectin.

KEYWORDS:

Adiponectin; Curcumin; Meta-analysis; Randomized controlled trials

PMID:
31425942
DOI:
10.1016/j.dsx.2019.07.045

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