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Curr Opin Cell Biol. 2019 Aug 16;61:92-100. doi: 10.1016/j.ceb.2019.07.009. [Epub ahead of print]

Recent advances in deriving human endodermal tissues from pluripotent stem cells.

Author information

1
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
2
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States; Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States; Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States. Electronic address: james.wells@cchmc.org.

Abstract

The utilization of directed differentiation of human pluripotent stem cells to generate human tissues is quickly evolving. Here we review recent advances in the derivation and applications of human endodermal tissues, including the esophagus, lung, pancreas, liver, stomach, small intestine, and colon. Improvements in tissue transcriptional and functional maturation, multicellular complexity, and scalability allow better development and disease modeling, large-scale drug and toxicity screening, and potentially cell therapeutic applications.

PMID:
31425933
DOI:
10.1016/j.ceb.2019.07.009

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