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Magn Reson Imaging. 2019 Nov;63:159-169. doi: 10.1016/j.mri.2019.08.008. Epub 2019 Aug 16.

Free-running simultaneous myocardial T1/T2 mapping and cine imaging with 3D whole-heart coverage and isotropic spatial resolution.

Author information

1
School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom. Electronic address: haikun.qi@kcl.ac.uk.
2
School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
3
Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China.
4
School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom; Escuela de Ingeniería, Pontificia Universidad Católica de Chile, Santiago, Chile.

Abstract

PURPOSE:

To develop a free-running framework for 3D isotropic simultaneous myocardial T1/T2 mapping and cine imaging.

METHODS:

Continuous data acquisition with 3D golden angle radial trajectory is used in conjunction with T2 preparation of varying echo times and inversion recovery (IR) pulses to enable simultaneous myocardial T1/T2 mapping and cine imaging. Data acquisition is retrospectively synchronized with ECG signal, and 1D respiratory self-navigation signal is extracted from the k-space center of all radial spokes. Respiratory binning is performed based on the estimated respiratory signal, enabling estimation and correction of 3D translational respiratory motion. Using high-dimensionality patch-based undersampled reconstruction with dictionary-based low-rank inversion, whole-heart T1/T2 maps and cine images can be generated with 2 mm isotropic spatial resolution. The proposed technique was validated in a standardised phantom and ten healthy subjects in comparison to conventional 2D imaging techniques.

RESULTS:

Phantom T1 and T2 measurements demonstrated good agreement with 2D spin echo techniques. Septal T1 estimated with the proposed technique (1185.6 ± 49.8 ms) was longer than with a conventional breath-hold 2D IR-prepared sequence (1044.3 ± 26.7 ms), whereas T2 measurements (47.6 ± 2.5 ms) were lower than a breath-hold 2D gradient spin echo sequence (52.0 ± 1.8 ms). Precision of the proposed 3D mapping was higher than conventional 2D mapping techniques. Ejection fraction measured with the proposed 3D approach (63.8 ± 6.8%) agreed well with conventional breath-held multi-slice 2D cine (62.3 ± 6.4%).

CONCLUSIONS:

The proposed technique provides co-registered 3D T1/T2 maps and cine images with isotropic spatial resolution from a single free-breathing scan, thereby providing a promising imaging tool for whole-heart myocardial tissue characterization and functional evaluation.

KEYWORDS:

3D radial; Cine imaging; Joint T1/T2; Myocardial T1 mapping; Myocardial T2 mapping

PMID:
31425810
DOI:
10.1016/j.mri.2019.08.008

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