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Biochem Biophys Res Commun. 1988 Oct 31;156(2):762-8.

Variant apolipoprotein AI as a major constituent of a human hereditary amyloid.

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Department of Medical Genetics, Indiana University School of Medicine, Indianapolis.


Amyloid fibrils were isolated from spleen and liver of a patient who died with Familial Amyloidotic Polyneuropathy Type III (Iowa). The major protein constituent of the fibrils was found to be the amino terminal portion (residues 1-83) of apolipoprotein AI with an arginine for glycine substitution at position 26. This is the first report of an apolipoprotein as a major amyloid constituent in a form of autosomal dominant hereditary amyloidosis in humans.

[Indexed for MEDLINE]

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