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Indian J Med Microbiol. 2019 Jan-Mar;37(1):127-131. doi: 10.4103/ijmm.IJMM_19_94.

Pulmonary Mycobacterium kyorinense disease: A case report and review of literature.

Author information

1
Department of HIV, ICMR-National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.
2
Department of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.
3
Department of Bacteriology, ICMR-National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.

Abstract

We report here the first case of pulmonary infection due to Mycobacterium kyorinense in a 55-year-old hypertensive woman treated for pulmonary tuberculosis earlier on two occasions. She presented with productive cough, intermittent episode of left-sided chest pain, loss of appetite, low-grade fever, and breathlessness. Sputum cultures revealed non-tuberculous mycobacteria (NTM). She remained persistently symptomatic with sputum cultures positive for acid-fast bacilli even after 6 months of treatment. Hence, a 16SrRNA gene amplification and sequencing were done that revealed M. kyorinense. Based on the guidelines of the American Thoracic Society, she was started on weight-based dosing of clarithromycin, levofloxacin, ethambutol, isoniazid and injection amikacin daily. The patient improved symptomatically and became culture-negative after 3 months of therapy with the above regimen and continued to be culture negative for 12 months of treatment. She continues to remain symptom-free without evidence of any clinical or bacteriological relapse.

KEYWORDS:

16SrRNA; non-tuberculous mycobacteria; rifampicin resistance

PMID:
31424025
DOI:
10.4103/ijmm.IJMM_19_94
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