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Indian J Med Microbiol. 2019 Jan-Mar;37(1):102-104. doi: 10.4103/ijmm.IJMM_19_84.

Distribution of human leucocyte antigen-C in HIV-1-infected patients in Mumbai, India.

Author information

1
Department of Infectious Diseases Biology, ICMR-National Institute for Research in Reproductive Health, Mumbai, Maharashtra, India.
2
Department of Obstetrics and Gynaecology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
3
Department of Microbiology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Abstract

HIV pathogenesis is known to be highly influenced by host genetic factors, such as human leucocyte antigens (HLAs) HLA-A and HLA-B. However, the role of HLA-C remains largely unexplored. We evaluated HLA-C distribution in 186 HIV-1-infected individuals and compared them to ethnically matched data derived from the Allele Frequency Net Database using Chi-square test with Fisher's exact two-tailed test. The frequency of HLA-C*05 and HLA-C*15 was higher in infected group, whereas the frequency of HLA-C*04 and HLA-C*14 was higher in control group. HLA-C*17, a rare allele, was significantly higher in infected group. These data could be useful in designing and testing vaccines in Indian population.

KEYWORDS:

HIV-1; India; human leucocyte antigen-C

PMID:
31424018
DOI:
10.4103/ijmm.IJMM_19_84
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