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Hum Brain Mapp. 2019 Aug 18. doi: 10.1002/hbm.24763. [Epub ahead of print]

Delineating functional segregations of the human middle temporal gyrus with resting-state functional connectivity and coactivation patterns.

Xu J1,2, Lyu H3, Li T1, Xu Z1, Fu X1, Jia F1, Wang J4, Hu Q1.

Author information

1
Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
2
University of Chinese Academy of Sciences, Beijing, China.
3
Radiology Department, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
4
Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

Abstract

Although the middle temporal gyrus (MTG) has been parcellated into subregions with distinguished anatomical connectivity patterns, whether the structural topography of MTG can inform functional segregations of this area remains largely unknown. Accumulating evidence suggests that the brain's underlying organization and function can be directly and effectively delineated with resting-state functional connectivity (RSFC) by identifying putative functional boundaries between cortical areas. Here, RSFC profiles were used to explore functional segregations of the MTG and defined four subregions from anterior to posterior in two independent datasets, which showed a similar pattern with MTG parcellation scheme obtained using anatomical connectivity. The functional segregations of MTG were further supported by whole brain RSFC, coactivation, and specific RFSC, and coactivation mapping. Furthermore, the fingerprint with predefined 10 networks and functional characterizations of each subregion using meta-analysis also identified functional distinction between subregions. The specific connectivity analysis and functional characterization indicated that the bilateral most anterior subregions mainly participated in social cognition and semantic processing; the ventral middle subregions were involved in social cognition in left hemisphere and auditory processing in right hemisphere; the bilateral ventro-posterior subregions participated in action observation, whereas the left subregion was also involved in semantic processing; both of the dorsal subregions in superior temporal sulcus were involved in language, social cognition, and auditory processing. Taken together, our findings demonstrated MTG sharing similar structural and functional topographies and provide more detailed information about the functional organization of the MTG, which may facilitate future clinical and cognitive research on this area.

KEYWORDS:

coactivation connectivity; connectivity-based parcellation; middle temporal gyrus; resting-state functional connectivity

PMID:
31423713
DOI:
10.1002/hbm.24763

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