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Theor Biol Med Model. 2019 Aug 19;16(1):12. doi: 10.1186/s12976-019-0107-3.

Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green.

Author information

1
Jinzhou Medical University, Jinzhou, 121000, China.
2
Department of Oncology, Graduate Training Base- Fourth Medical Center of Chinese PLA General Hospital of Jinzhou Medical University, Beijing, 100048, China.
3
School of Medicine, Nankai University, Tianjin, 300071, China.
4
Shenzhen University, Shenzhen, 518000, China.
5
Burns Institute, Fourth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China.
6
Department of laboratory animal, Fourth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China.
7
Department of Oncology, Fourth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China.
8
Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian, 116000, Liaoning, China.
9
Department of Oncology, Fourth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China. doctor301@sohu.com.
10
Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, College of Mathematics and Science, University of Central Oklahoma, Edmond, 73034, USA.

Abstract

BACKGROUND:

Photothermal therapy is a local treatment method for cancer and the heat energy generated from it could destroy the tumor cells. This study is aimed to investigate the temperature distribution in tumor tissue and surrounding health tissue of tumor bearing mice applying mathematical simulation model. Tumor bearing mice treated by laser combined with or without indocyanine green. Monte Carlo method and the Pennes bio-heat equation were used to calculate the light distribution and heat energy. COMSOL Multiphysic was adopted to construct three dimensional temperature distribution model.

RESULTS:

This study revealed that the data calculated by simulation model is in good agreement with the surface temperature monitored by infrared thermometer. Effected by the optical parameters and boundary conditions of tissue, the highest temperature of tissue treated by laser combined with indocyanine green was about 65 °C which located in tumor tissue and the highest temperature of tissue treated by laser was about 43 °C which located under the tumor tissue. The temperature difference was about 20 °C. Temperature distribution in tissue was not uniform. The temperature difference in different parts of tumor tissue raised up to 15 °C. The temperature of tumor tissue treated by laser combined with indocyanine green was about 20 °C higher than that of the surrounding healthy tissue.

CONCLUSIONS:

Reasonably good matching between the calculated temperature and the measured temperature was achieved, thus demonstrated great utility of our modeling method and approaches for deepening understand in the temperature distribution in tumor tissue and surrounding healthy tissue during the laser combined with photosensitizer. The simulation model could provide guidance and reference function for the effect of photothermal therapy.

KEYWORDS:

COMSOL Multiphysics; Indocyanine green; Monte Carlo; Pennes bio-equation; Photothermal therapy; Temperature distribution

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