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Curr Med Chem. 2019 Aug 16. doi: 10.2174/0929867326666190816230121. [Epub ahead of print]

Parthenolide and Its Analogues: A New Potential Strategy for the Treatment of Triple-Negative Breast Tumors.

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Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, Minas Gerais,. Brazil.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais,. Brazil.


Triple negative breast cancers (TNBC) are heterogeneous and aggressive pathologies, with distinct morphological and clinical characteristics associated with their genetic diversity, epigenetics, transcriptional changes and aberrant molecular patterns. Treatment with anti-neoplastic drugs exerts systemic effects with low specificity, and incipient improvement in overall survival due to chemoresistance and recurrence. New alternatives for TNBC treatment are urgent and parthenolide or its analogues have been explored. Parthenolide is a sesquiterpene lactone with promising antitumor effects against TNBC cell lines. This review highlights the importance of parthenolide and its analogue drugs in TNBC treatment.


Parthenolide; heterogeneity; natural products.; nuclear factor-κ; sesquiterpene lactones; triple negative breast cancer

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