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Osteoporos Int. 2019 Aug 15. doi: 10.1007/s00198-019-05109-0. [Epub ahead of print]

Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010.

Abtahi S1,2,3, Driessen JHM1,2,3,4, Vestergaard P5,6, van den Bergh J4,7,8,9, Boonen A2,7, de Vries F10,11,12, Burden AM1,2,3.

Author information

1
Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center+, Maastricht, The Netherlands.
2
Care and Public Health Research Institute (CAPHRI), Maastricht, The Netherlands.
3
Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands.
4
NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.
5
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
6
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
7
Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center+, Maastricht, The Netherlands.
8
Department of Internal Medicine, VieCuri Medical Center, Venlo, The Netherlands.
9
Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.
10
Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center+, Maastricht, The Netherlands. frank.de.vries@mumc.nl.
11
Care and Public Health Research Institute (CAPHRI), Maastricht, The Netherlands. frank.de.vries@mumc.nl.
12
Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands. frank.de.vries@mumc.nl.

Abstract

We investigated the incidence trend in all major osteoporotic fractures for the whole country of Denmark between 1995 and 2010. Hip and other osteoporotic fractures declined for the general population and especially among women. But, we observed some increasing trend among men which needs more attention.

PURPOSE:

The trend in osteoporotic fractures is varied across the globe, and there is no updated information in the case of Denmark for all major osteoporotic fractures (MOF). Thus, we investigated the incidence rates (IRs) of MOF among 50+ adults in Denmark over the period 1995-2010.

METHODS:

A series of cross-sectional analyses was done using the Danish National Health Service Register. Participants were 50+ adults in the full country Denmark with a MOF between 1995 and 2010. Gender- specific IRs of MOF per 10,000 person years (PYs) were estimated, in addition to IRs of individual fracture sites (hip, vertebrae, humerus, and radius/ulna), and women-to-men IR ratios for MOF.

RESULTS:

A general decline was observed in IRs of MOF for the whole population (from 169.8 per 10,000 PYs in 1995, to 148.0 in 2010), which was more pronounced among women. Thirty-one and nineteen percent of decline was observed in hip fracture rates among women and men, respectively. The trend in clinical vertebral fracture was slightly decreasing for women and increasing for men. The women-to-men rate ratio of MOF decreased noticeably from 2.93 to 2.72 during study period.

CONCLUSIONS:

We observed declining trends in MOF and hip fracture for both sexes. However, a lower rate of decrease of hip fracture and an increasing trend in vertebral fracture was noticed among men. Considering our observations and the major economic burden that accompanies this devastating disease, more attention should be paid to MOF, especially in men.

KEYWORDS:

Epidemiology; Incidence rates; Osteoporosis; Osteoporotic fractures

PMID:
31418061
DOI:
10.1007/s00198-019-05109-0

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