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Endosc Ultrasound. 2019 Aug 13. doi: 10.4103/eus.eus_38_19. [Epub ahead of print]

Prospective comparison study of franseen needle and standard needle use for pancreatic lesions under EUS guidance.

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2nd Department of Internal Medicine, Osaka Medical College, Osaka, Japan.
Department of Pathology, Osaka Medical College, Osaka, Japan.


Background and Objectives:

A needle with Franseen geometry for fine needle aspiration is now available. However, no reports have described prospective evaluations of the Franseen needle or comparisons with the standard needle. The aim of this comparative prospective study was to evaluate the histological diagnostic yield of the Franseen needle and the standard needle using tissue obtained by a single pass of each for the same lesion.

Patients and Methods:

In this study, only tissue obtained by the first pass using the Franseen needle was used. As a comparison group, only tissue obtained from the same lesion by a second pass using the standard needle was used. Evaluation of the histological diagnostic yield of the needles was based on tissue obtained by each single pass with no additional passes.


A total of 56 patients were prospectively enrolled. The rate of adequate tissue obtained was significantly higher for the Franseen needle than for the standard needle (89.4% vs. 62.5%, respectively; P < 0.05). The sensitivity and accuracy of the Franseen needle were 80.7%, and 84.6%, respectively, while those for the standard needle were 59.6% and 63.5%, respectively.


The Franseen needle offers a better rate of obtaining adequate tissue and higher diagnostic accuracy than the standard needle.


EUS; EUS-FNA; Franseen needle; pancreatic cancer

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