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Neuroimage. 2019 Aug 12;202:116091. doi: 10.1016/j.neuroimage.2019.116091. [Epub ahead of print]

Image processing and analysis methods for the Adolescent Brain Cognitive Development Study.

Hagler DJ Jr1, Hatton S2, Cornejo MD2, Makowski C3, Fair DA4, Dick AS5, Sutherland MT5, Casey BJ6, Barch DM7, Harms MP7, Watts R6, Bjork JM8, Garavan HP9, Hilmer L2, Pung CJ2, Sicat CS2, Kuperman J2, Bartsch H2, Xue F2, Heitzeg MM10, Laird AR5, Trinh TT2, Gonzalez R5, Tapert SF2, Riedel MC5, Squeglia LM11, Hyde LW10, Rosenberg MD6, Earl EA4, Howlett KD12, Baker FC13, Soules M10, Diaz J2, de Leon OR2, Thompson WK2, Neale MC8, Herting M14, Sowell ER15, Alvarez RP16, Hawes SW5, Sanchez M5, Bodurka J17, Breslin FJ17, Morris AS17, Paulus MP17, Simmons WK17, Polimeni JR18, van der Kouwe A18, Nencka AS19, Gray KM11, Pierpaoli C20, Matochik JA21, Noronha A21, Aklin WM12, Conway K12, Glantz M12, Hoffman E12, Little R12, Lopez M12, Pariyadath V12, Weiss SR12, Wolff-Hughes DL22, DelCarmen-Wiggins R23, Feldstein Ewing SW4, Miranda-Dominguez O4, Nagel BJ4, Perrone AJ4, Sturgeon DT4, Goldstone A13, Pfefferbaum A13, Pohl KM13, Prouty D13, Uban K24, Bookheimer SY25, Dapretto M25, Galvan A25, Bagot K2, Giedd J2, Infante MA2, Jacobus J2, Patrick K2, Shilling PD2, Desikan R26, Li Y26, Sugrue L26, Banich MT27, Friedman N27, Hewitt JK27, Hopfer C27, Sakai J27, Tanabe J27, Cottler LB28, Nixon SJ28, Chang L29, Cloak C29, Ernst T29, Reeves G29, Kennedy DN30, Heeringa S10, Peltier S10, Schulenberg J10, Sripada C10, Zucker RA10, Iacono WG31, Luciana M31, Calabro FJ32, Clark DB32, Lewis DA32, Luna B32, Schirda C32, Brima T33, Foxe JJ33, Freedman EG33, Mruzek DW33, Mason MJ34, Huber R35, McGlade E35, Prescot A35, Renshaw PF35, Yurgelun-Todd DA35, Allgaier NA9, Dumas JA9, Ivanova M9, Potter A9, Florsheim P36, Larson C36, Lisdahl K36, Charness ME37, Fuemmeler B8, Hettema JM8, Maes HH8, Steinberg J8, Anokhin AP7, Glaser P7, Heath AC7, Madden PA7, Baskin-Sommers A6, Constable RT6, Grant SJ12, Dowling GJ12, Brown SA2, Jernigan TL2, Dale AM2.

Author information

University of California, San Diego, United States. Electronic address:
University of California, San Diego, United States.
McGill University, Montreal, Canada.
Oregon Health & Science University, United States.
Florida International University, United States.
Yale University, United States.
Washington University, St. Louis, United States.
Virginia Commonwealth University, United States.
University of Vermont, United States.
University of Michigan, United States.
Medical University of South Carolina, United States.
National Institute on Drug Abuse, United States.
SRI International, United States.
University of Southern California, United States; Children's Hospital of Los Angeles, United States.
Children's Hospital of Los Angeles, United States.
Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States.
Laureate Institute for Brain Research, Tulsa, United States.
Massachusetts General Hospital, United States; Harvard Medical School, United States.
Medical College of Wisconsin, United States.
National Institute of Biomedical Imaging and Bioengineering, United States.
National Institute on Alcohol Abuse and Alcoholism, United States.
Office of Behavioral and Social Sciences Research, United States.
Office of Research on Women's Health, United States.
University of California, Irvine, United States.
University of California, Los Angeles, United States.
University of California, San Francisco, United States.
University of Colorado, United States.
University of Florida, United States.
University of Maryland School of Medicine, United States.
University of Massachusetts, United States.
University of Minnesota, United States.
University of Pittsburgh, United States.
University of Rochester, United States.
University of Tennessee, United States.
University of Utah, United States.
University of Wisconsin-Milwaukee, United States.
Harvard Medical School, United States; VA Boston Healthcare System, United States; Boston University School of Medicine, United States.


The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing, nationwide study of the effects of environmental influences on behavioral and brain development in adolescents. The main objective of the study is to recruit and assess over eleven thousand 9-10-year-olds and follow them over the course of 10 years to characterize normative brain and cognitive development, the many factors that influence brain development, and the effects of those factors on mental health and other outcomes. The study employs state-of-the-art multimodal brain imaging, cognitive and clinical assessments, bioassays, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning. The data is a resource of unprecedented scale and depth for studying typical and atypical development. The aim of this manuscript is to describe the baseline neuroimaging processing and subject-level analysis methods used by ABCD. Processing and analyses include modality-specific corrections for distortions and motion, brain segmentation and cortical surface reconstruction derived from structural magnetic resonance imaging (sMRI), analysis of brain microstructure using diffusion MRI (dMRI), task-related analysis of functional MRI (fMRI), and functional connectivity analysis of resting-state fMRI. This manuscript serves as a methodological reference for users of publicly shared neuroimaging data from the ABCD Study.


ABCD; Adolescent; Data sharing; Magnetic resonance imaging; Processing pipeline

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