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Anal Chem. 2019 Sep 17;91(18):12070-12076. doi: 10.1021/acs.analchem.9b03230. Epub 2019 Aug 27.

A Single Fluorescent Chemosensor for Simultaneous Discriminative Detection of Gaseous Phosgene and a Nerve Agent Mimic.

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Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion , Tianjin University of Technology , Tianjin 300384 , P.R. China.
School of Chemistry and Materials Science , Hubei Engineering University , Xiaogan 432000 , P.R. China.
College of Chemistry and Chemical Engineering , Xinyang Normal University , Xinyang 464000 , P.R. China.
Department of Chemistry and Nano Science , Ewha Womans University , Seoul 03760 , Korea.


A fluorescent chemosensor has been developed for discriminative detection of phosgene and a nerve agent mimic diethyl chlorophosphate (DCP), which was comprised of an anthracene-carboxyimide fluorophore and o-phenylenediamine (OPD) reaction site. Upon phosphorylation of OPD, the chemosensor displays an obvious fluorescence turn-on response toward DPC at 588 nm with instant response and a low detection limit (88 nM). By contrast, the chemosensor exhibits a colorimetric and fluorescence enhancement response at 500 nm toward phosgene with fast response (<2 min), high selectivity, and a low detection limit (72 nM). Furthermore, chemosensor-loaded test membrane was fabricated for real-time, portable and efficient discriminative detection of trace amounts of gaseous phosgene and DCP vapor with different optical responses.

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