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Diabetologia. 2019 Nov;62(11):1961-1968. doi: 10.1007/s00125-019-4969-z. Epub 2019 Aug 14.

VEGF-A and blood vessels: a beta cell perspective.

Author information

1
Beta Cell Neogenesis (BENE), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium.
2
Institut Cochin, CNRS, INSERM, Université de Paris, F-75014, Paris, France.
3
Beta Cell Neogenesis (BENE), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium. Nico.De.Leu@vub.be.
4
Department of Endocrinology, UZ Brussel, Brussels, Belgium. Nico.De.Leu@vub.be.
5
Department of Endocrinology, ASZ Aalst, Aalst, Belgium. Nico.De.Leu@vub.be.

Abstract

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult pancreas, islets depend on their dense capillary network to adequately respond to changes in plasma glucose levels. Vascular changes contribute to the onset and progression of both type 1 and type 2 diabetes. Impaired revascularisation of islets transplanted in individuals with type 1 diabetes is linked to islet graft failure and graft loss. This review summarises our understanding of the role of vascular endothelial growth factor-A (VEGF-A) and endothelial cells in beta cell development, physiology and disease. In addition, the therapeutic potential of modulating VEGF-A levels in beta and beta-like cells for transplantation is discussed.

KEYWORDS:

Blood vessels; Diabetes; Endothelial cells; Pancreatic beta cells; Review; VEGF-A

PMID:
31414144
DOI:
10.1007/s00125-019-4969-z

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