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Transl Pediatr. 2019 Jul;8(3):170-181. doi: 10.21037/tp.2019.07.06.

The International Network for Evaluating Outcomes (iNeo) of neonates: evolution, progress and opportunities.

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Department of Pediatrics, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada.
Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada.
Royal Hospital for Women, National Perinatal Epidemiology and Statistic Unit, University of New South Wales, Randwick, Australia.
Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Centre, Ramat Gan, Israel.
Department of Neonatal Medicine, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden.
Neonatal Research Network Japan, Maternal and Perinatal Center, Tokyo Women's Medical University, Tokyo, Japan.
Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Division of Neonatology and Health Research Institute La Fe, Valencia, Spain.
Department of Paediatrics, University of Otago, Christchurch, New Zealand.
UK Neonatal Collaborative, Neonatal Data Analysis Unit, Section of Neonatal Medicine, Department of Medicine, Imperial College London, Chelsea and Westminster Hospital campus, London, UK.
Neonatal Intensive Care Unit, Anna Meyer Children's University Hospital, Florence, Italy.
Department of Clinical Sciences/Pediatrics, Umeå University Hospital, Umeå, Sweden.
Division of Neonatology, University Hospital Salamanca, Salamanca, Spain.
Department of Neonatal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.
Department of Obstetrics and Gynecology and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.


Neonates born very preterm (before 32 weeks' gestational age), are a significant public health concern because of their high-risk of mortality and life-long disability. In addition, caring for very preterm neonates can be expensive, both during their initial hospitalization and their long-term cost of permanent impairments. To address these issues, national and regional neonatal networks around the world collect and analyse data from their constituents to identify trends in outcomes, and conduct benchmarking, audit and research. Improving neonatal outcomes and reducing health care costs is a global problem that can be addressed using collaborative approaches to assess practice variation between countries, conduct research and implement evidence-based practices. The International Network for Evaluating Outcomes (iNeo) of neonates was established in 2013 with the goal of improving outcomes for very preterm neonates through international collaboration and comparisons. To date, 10 national or regional population-based neonatal networks/datasets participate in iNeo collaboration. The initiative now includes data on >200,000 very preterm neonates and has conducted important epidemiological studies evaluating outcomes, variations and trends. The collaboration has also surveyed >320 neonatal units worldwide to learn about variations in practices, healthcare service delivery, and physical, environmental and manpower related factors and support services for parents. The iNeo collaboration serves as a strong international platform for Neonatal-Perinatal health services research that facilitates international data sharing, capacity building, and global efforts to improve very preterm neonate care.


Preterm infants; neonatal intensive care; outcomes research

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Conflicts of Interest: The authors have no conflicts of interest to declare.

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