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Urol Ann. 2019 Jul-Sep;11(3):261-264. doi: 10.4103/UA.UA_161_17.

Chronic scrotal pain: A variable symptom of interstitial cystitis/bladder pain syndrome.

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Department of Surgery/Urology, UC San Diego Medical Center, San Diego, CA, USA.



Treatment of chronic idiopathic scrotal pain is a dilemma and challenge. Many men with this condition undergo multiple therapies and surgeries with no improvement in their symptoms. Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) have a variable clinical presentation and initially complain of only one symptom of urinary urgency, frequency, or pain. We report on patients with chronic idiopathic scrotal pain treated with standard therapy for IC/BPS.

Patients and Methods:

Patients with chronic idiopathic scrotal content pain were evaluated, determined to have chronic idiopathic scrotal content pain, and were treated with either pentosan polysulfate sodium (PPS) or bladder instillations of alkalinized lidocaine and heparin.


Sixteen males were determined to have chronic idiopathic scrotal pain. Eight males received PPS and eight males received a bladder instillation of alkalinized lidocaine and heparin. All patients had improvement of their scrotal pain to a self-reported acceptable level.


Chronic idiopathic scrotal pain may be one of the variable presenting symptoms of IC/BPS. This scrotal pain may actually be referred pain from the bladder. Standard therapies for IC/BPS may be a treatment option for chronic idiopathic scrotal pain.


Bladder instillation; bladder pain syndrome; chronic scrotal pain; idiopathic scrotal pain; interstitial cystitis; orchialgia

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