Format

Send to

Choose Destination
Pharmacol Res. 2019 Sep;147:104395. doi: 10.1016/j.phrs.2019.104395. Epub 2019 Aug 11.

Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia.

Author information

1
University of Western São Paulo, Presidente Prudente, São Paulo, Brazil.
2
College of Health, Life and Environmental Sciences, University of Worcester, United Kingdom.
3
School of Medicine, Federal University of Uberlândia (UFU), Uberlandia, Minas Gerais, Brazil. Electronic address: heitoroliveirasantos@gmail.com.

Abstract

Anxiety disorders are highly prevalent in modern societies, and are ranked the sixth most important contributor of non-fatal negative health outcomes. L-theanine is an amino acid naturally found in green tea (Camellia sinensis) and some other plant extracts, and recent clinical studies have proposed promising adjuvant effects of L-theanine for the negative impact of anxiety and psychological stress on health. In this integrative narrative review, we aimed to appraise and further discuss the effects of L-theanine administration on anxiety disorders and psychological stress. Published data suggests that L-theanine administered at daily doses ranging from 200 to 400 mg for up to 8 weeks are safe and induce anxiolytic and anti-stress effects in acute and chronic conditions. L-theanine at doses lower and higher than these may also show promising therapeutic potential; however, a more thorough investigation through randomized double-blind placebo-controlled crossover clinical trials are necessary to elucidate its effects for longer periods, providing further insights for meta-analyses and the development of recommendation guidelines. Additionally, animal studies investigating a higher dosage, its combination with other pharmacological compounds and associated metabolic comorbidities are recommended, as cases of hepatotoxicity associated with the consumption of green tea extract have been reported.

KEYWORDS:

(L)-theanine; Anxiety; Camellia sinensis; Green tea; Psychological stress; Schizophrenia

PMID:
31412272
DOI:
10.1016/j.phrs.2019.104395

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center