Cooperation of oncolytic virotherapy with VEGF-neutralizing antibody treatment in IDH wildtype glioblastoma depends on MMP9

Neuro Oncol. 2019 Dec 17;21(12):1607-1609. doi: 10.1093/neuonc/noz145.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Neutralizing / pharmacology*
  • Brain Neoplasms / genetics
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / pathology
  • Brain Neoplasms / therapy*
  • Combined Modality Therapy
  • Glioblastoma / genetics
  • Glioblastoma / metabolism
  • Glioblastoma / pathology
  • Glioblastoma / therapy*
  • Humans
  • Isocitrate Dehydrogenase / genetics
  • Matrix Metalloproteinase 9 / metabolism*
  • Mice
  • Mutation*
  • Oncolytic Virotherapy / mortality*
  • Survival Rate
  • Tumor Cells, Cultured
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors*
  • Vascular Endothelial Growth Factor A / immunology
  • Xenograft Model Antitumor Assays

Substances

  • Antibodies, Neutralizing
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • IDH2 protein, human
  • Isocitrate Dehydrogenase
  • IDH1 protein, human
  • MMP9 protein, human
  • Matrix Metalloproteinase 9